Substitution at R3 having a halogen or alkoxy group (74f–74i) resulted in a slight increase in cellular potency with the halide analogs (74g–h) showing best the potency during the group. Further optimization triggered the invention of 74i–j, with 74k as one of the most Energetic compound within the collection (pIC50 https://buyindazole75318.newsbloger.com/32024360/the-single-best-strategy-to-use-for-indazole-protecting-group