Gastrointestinal (GI): NSAIDs that block COX-1 action have correlations with GI difficulties mainly because of the inhibition on the synthesis of gastroprotective agents for instance PGE2 and other prostaglandins. This inhibition causes reduced mucin production by gastric epithelial cells, less bicarbonate secretion, and fewer epithelial mobile turnover, amongst other actions. https://jasperpvvqm.blogdemls.com/29493291/5-easy-facts-about-diclofenac-sodium-described