In people who could possibly be liable to intracranial effects of CO2 retention (e.g., those with proof of improved intracranial stress or Mind tumors), therapy could lessen respiratory generate, and resultant CO2 retention can additional enhance intracranial pressure; observe this sort of patients for indications of sedation and respiratory despair, https://wockusa.com/product/fentanyl-100-mcg-hr-transdermal-patch/