In this particular report, we executed a whole protein-coding genome RNA interference (RNAi) screen to recognize opportunity targets whose inhibition can improve the efficacy of CX-5461 in treating HR-proficient HGSC. We show the CX-5461 displays a novel sensitivity sample distinct to those claimed for G-quadruplex stabilisers and topoisomerase two (TOP2) https://williami665whr8.wiki-cms.com/user